- ALT-TRACC
ALT-TRACC is part of the AGITG Endorsed Study Model (please click here to find out more)
Trial Status
Open / Endorsed Studies
Cancer Type
Colorectal Cancer
If you think this trial is relevant to your situation, please contact your Cancer Specialist to discuss further.
Protocol Title
Alternating oxaliplatin and irinotecan doublet schedules versus continuous doublet chemotherapy in previously untreated metastatic colorectal cancer: A Treatment of Recurrent and Advanced Colorectal Cancer registry-based prospective randomised trial
Purpose of the Study
The purpose of this study is to determine the efficacy of alternating oxaliplatin and irinotecan doublet schedules versus continuous doublet chemotherapy in previously untreated metastatic colorectal cancer.
ELIGIBILITY CRITERIA
Inclusion Criteria
- Signed informed consent obtained prior to any study specific procedures and willingness to comply with study requirements
- Age ≥18 years
- Histologically confirmed, metastatic colorectal adenocarcinoma treated with ≤ 2 cycles of doublet chemotherapy
- ECOG performance status of 0-2
- Life expectancy of ≥3 months
- Adequate major organ function to receive doublet chemotherapy as judged by the treating clinician
- Recent imaging of chest, abdomen and pelvis.
Exclusion Criteria
- Previous chemotherapy and/or biologic therapy for CRC, except (A) adjuvant treatment if completed more than 6 months earlier or (B) initial chemoradiation with single agent fluoropyrimidine for patients initially presenting with metastatic rectal cancer
- Not suitable for doublet chemotherapy
- Significant concomitant medical condition which the treating clinician believes precludes the patient from enrolling in the study
Contact Email
Mr Michael Harold – michael.harold@mh.org.au or Dr Vanessa Wong – wong.v@wehi.edu.au
Study Chairs
Dr Vanessa Wong
Prof Peter Gibbs
DETAILED INFORMATION AVAILABLE
More detailed information available online at the Australian New Zealand Clinical Trial Registry (ANZCTR) please click here.
Please contact Michael or Vanessa to request this information.
Funding
Victorian Comprehensive Cancer Centre
Patients Recruited
Click here to access the table and view recruitment data on all AGITG open trials:
Participating Centres
Trial Status
Open / Endorsed Studies
Cancer Type
Colorectal Cancer
If you think this clinical trial may be relevant to your patient or to discuss further, please contact the Clinical Trial team.